Revised dec 2016 this draft guidance, when finalized, will represent the current thinking of the food and drug administration fda, or the agency on this topic. But patient may need a dose adjustment or more frequent monitoring by his doctor to safely use both medications. Most common with oral acyclovir are lightheadedness, headache, diarrhea, nausea, vomiting and abdominal pain. Reconstitute 500mg or 1g vial with 10 ml or 20 ml, respectively, of sterile water for injection. Acyclovir is widely distributed into tissues and body fluids. Possible interaction between acyclovir and antiepileptic treatment. The drug may be administered topically to the skin, intravenously, orally, or topically to the eye only topical and intravenous preparations are currently. Penciclovir susceptibilities of herpes simplex virus. History, pharmacokinetics, and pharmacology of acyclovir. Shingrix zoster vaccine recombinant, adjuvanted suspension for intramuscular injection. Individual and family medical and dental insurance plans are insured by cigna health and life insurance company chlic, cigna healthcare of arizona, inc.
Antivirales universidad centroccidental lisandro alvarado. Shingrix zoster vaccine recombinant, adjuvanted is a sterile suspension for intramuscular injection. Do not administer acyclovir injectable topically, im, subcut, po, or in the eye. Penciclovir susceptibilities of herpes simplex virus isolates from patients using penciclovir cream for treatment of recurrent herpes labialis. Acyclovir is slowly and poorly absorbed from the gastrointestinal tract and bioavailability decreases with increasing dose. Renal excretion is the major route of elimination of acyclovir. It shows good in vitro activity against herpes simplex and varicella. The vaccine is supplied as a vial of lyophilized recombinant varicella zoster virus surface glycoprotein e ge antigen component, which must. Acyclovir is a new antiviral drug that acts as a specific inhibitor of herpesvirus dna polymerase. This draft guidance, when finalized, will represent the. Plasma protein binding is relatively low at 9 to 24%. We performed pubmed database searches through june 2014 for relevant studies in the english literature. A read is counted each time someone views a publication summary such as the title, abstract, and list of authors, clicks on a figure, or views or downloads the fulltext.
785 1502 550 494 347 618 918 965 894 819 1079 489 1306 321 472 522 737 421 1259 278 1163 914 46 534 742 1454 14 609 454 1115 191 1322 928 32 124 155 775